3301 N. High St., Clintonville
You love some Rag-O-Rama, don't you, dear readers? Although the Clintonville spot is technically more a well-edited vintage shop than an old-school thrift store, the only distinction that matters in the minds of voters is it's the spot for the good stuff. Fans followed the store to new digs a few years back, after the place literally got too big for its britches. So what's the store's secret to success? You. And also that bag of gently used clothes you've been meaning to bring in.
Runners-up: Goodwill, Ohio Thrift