3169 N. High St., Clintonville
This little shop is the living embodiment of Columbus' status as Indie Art Capital of the World. A wonderland for the arsty-craftsy set, it's filled with art, clothing, gifts and toys handmade by local crafters. Most items have tags identifying the artist, but owner Olivera Bratich is happy to fill you in if something doesn't. Plus, they not only sell crafting supplies to help get you started on making your own stuff, but also offer classes to teach you how.
Runners-up: North Market Artisan Sundays, Tigertree