The biggest problem with "The Voices" is that some of its potential fans might be put off by the leading man presence of Ryan Reynolds, while fans of previous Reynolds films like "The Proposal" might flee for the exits.

The biggest problem with “The Voices” is that some of its potential fans might be put off by the leading man presence of Ryan Reynolds, while fans of previous Reynolds films like “The Proposal” might flee for the exits.

But if the right viewers connect with the latest from director Marjane Satrapi (“Persepolis”), they’re in for a twisted delight: a tar-black, blood-drenched comedy about skipped medication and serial murder that’s genuinely beyond compare.

Reynolds plays Jerry Hickfang, a warehouse worker at a cotton candy-colored plumbing supply business. He’s also a psychotic who’s off his meds. At home, Jerry often converses with his supportive pet mastiff, Bosco, and his nefarious cat, Mr. Whiskers (voiced by Reynolds as a perfect aping of Jon Stewart doing Mitch McConnell and a burr-throated Scotsman, respectively).

It’s best not to know too much more going in. Just know that Jerry’s attempts to lead a normal life often turn tragically violent, and then insanely ridiculous, and his pets are always throwing in their two cents.

In a premise that had the potential to yield something awful, Satrapi and screenwriter Michael R. Perry find bracing originality and unexpected depth, and Reynolds nails the gentleness and confusion that coexist alongside Jerry’s animal instincts. Despite going to fantastic extremes, this tale of severe mental illness has a sympathetic heart.